化学所分子识别与功能实验室
学术带头人

       程靓 研究员

       

        电话:+86-10-61943102

        传真:+86-10-62554449

        邮箱:chengl@iccas.ac.cn

        课题组主页:http://people.ucas.ac.cn/~chengl

     

    学术经历

    2000–2004   北京师范大学,学士学位

    2004–2009   中国科学院化学研究所,博士学位

    2009–2011   合成研究员,凯美隆(北京)药业技术有限公司,北京赛林泰医药技术有限公司

    2011–2014   美国哥伦比亚大学,博士后

    2015–至今    中国科学院化学研究所,研究员

     

    研究方向

    化学生物学是一门利用外源的化学物质、化学方法或途径,在分子层面上对生命体系进行精准的修饰、调控和阐释的学科。作为化学生物学重要的研究方向之一,研究发展能够与RNA发生相互作用的化学分子,不仅可以用来作为研究核酸性质与功能的探针,还有可能被进一步开发,用来作为控制生物体运动与行为的活性物质。我们的研究兴趣是开发结构新颖、易于合成和修饰的有机分子化合物,进而发展针对RNA的特异性高级结构具有较高识别性能的小分子体系,同时开展具有生物活性的天然产物和重要的药物分子的合成研究。具体研究方向包括:

    1. 基于RNA的化学生物学

    2. 生物活性分子的合成方法学

     

    Selected Work

    1. Biomimetic Binding and Cleavage of RNA by Synthetic Deoxypolypeptides (DOPPs)

     

    2. Tunneling in Base-Catalyzed Isomerization of GLA to DHA under Formose Conditions

     

    3. Discovery and Development of FAK/Pyk2 Dual Inhibitor CT-707

     

    4. Chemo- and Enantio-selective C-H Functionalization of Indole Derivatives

     

    Selected Publications

    1. Huang, H.-Y.; Cheng, L.*; Liu, J.-J.; Wang, D.; Liu, L.*; Li, C.-J.* "Transition-Metal-Free Alkynylation of 2-Oxindoles through Radical-Radical Coupling", J. Org. Chem. 2017, 82, 2656-2663.

    2. Wei, F.; Cheng, L.*; Huang, H.-Y.; Liu, J.-J.; Wang, D.; Liu, L.* "Intermolecular Dearomative Oxidative Coupling of Indoles with Ketones and Sulfonylhydrazines Catalyzed by I2 for the Synthesis of [2,3]-Fused Indoline Tetrahydropyridazines", Sci. China Chem. 2016, 59, 1311-1316.

    3. Kong, D.-L.; Cheng, L.*; Yue, T.; Wu, H.-R.; Feng, W.-C.; Wang, D.; Liu, L.* "Cobalt-Catalyzed Peroxidation of 2-Oxindoles with Hydroperoxides", J. Org. Chem. 2016, 81, 5337-5344.

    4. Wu, H.-R.; Cheng, L.; Kong, D.-L.; Huang, H.-Y.; Gu, C.-L.; Liu, L.*; Wang, D.; Li, C.-J.* “FeCl3-mediated radical tandem reactions of 3-benzyl-2-oxindoles with styrene derivatives for the stereoselective synthesis of spirocyclohexene oxindoles”, Org. Lett. 2016, 18, 1382–1385.

    5. Li, X.-D.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L.* “Metal-free allylation of electron-rich heteroaryl boronic acids with allylic alcohols”, Tetrahedron 2016, 72, 1873-1880.

    6. Kong, D.-L.; Cheng, L.; Wu, H.; Li, Y.; Wang, D.; Liu, L.* “Metal-free yne-addition/1,4-aryl migration/decarboxylation cascade reaction of alkynoates with Csp3-H centers”, Org. Biomol. Chem. 2016, 14, 2210−2217.

    7. Cheng, L.; Charles, D.*; Breslow, R.* “Evidence for tunneling in base-catalyzed isomerization of glyceraldehyde to dihydroxyacetone by hydride shift under formose conditions”, Proc. Natl. Acad. Sci. USA 2015, 112, 4218−4220.

    8. Cheng, L.; Mahendran, A.; Gonzalez, R. L. Jr.*; Breslow, R.* “Deoxypolypeptides bind and cleave RNA”, Proc. Natl. Acad. Sci. USA 2014, 111, 7920–7924.

    9. Cheng, L.; Abhilash, K. G.; Breslow, R.* “Binding and biomimetic cleavage of the RNA poly(U) by synthetic polyimidazoles”, Proc. Natl. Acad. Sci. USA 2012, 109, 12884−12887.

    10. Cheng, L.; Liu, L.*; Li, C.; Jia, H.; Wang, D.; Chen, Y. J.* “Nucleophilic addition of regioselectively lithiated indoline with aldimines for the syntheses of 2- and 7-indolinyl methanamine derivatives”, Tetrahedron Lett. 2012, 53, 4004−4007.

    11. Zhang, T.; Cheng, L.; Hameed, S.; Liu, L.*; Wang, D.; Chen, Y. J.* “Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea”, Chem. Commun. 2011, 47, 6644−6646.

    12. Zhang, T.; Cheng, L.; Liu, L.*; Wang, D.; Chen, Y. J.* “Asymmetric organocatalytic N-nitroso-aldol reaction of oxindoles”, Tetrahedron: Asymmetry 2010, 21, 2800−2806.

    13. Cheng, L.; Liu, L.*; Wang, D.; Chen, Y. J.* “Highly enantioselective and organocatalytic alpha-amination of 2-oxindoles”, Org. Lett. 2009, 11, 3874−3877.

    14. Cheng, L.; Liu, L.*; Jia, H.; Wang, D.; Chen, Y. J.* “Enantioselective organocatalytic anti-Mannich-type reaction of N-unprotected 3-substituted 2-oxindoles with aromatic N-Ts-aldimines”, J. Org. Chem. 2009, 74, 4650−4653.

    15. Cheng, L.; Liu, L.*; Sui, Y.; Wang, D.; Chen, Y. J.* “Highly diastereoselective reactions of 2-lithiated indoles with chiral N-tert-butanesulfinyl aldimines for the synthesis of chiral (2-indolyl) methanamine derivatives”, Tetrahedron: Asymmetry 2007, 18, 1833−1843.

    16. 校登明,程靓,刘希杰,胡远东,许新合,刘志华,张立鹏,吴伟,王树龙,沈宇,李根,王银,赵胜,李舂龙,唐佳,于洪灏,“作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物”,中国专利,授权号:ZL 201110002776.3,公告日:2015年1月28日。

    17. Xiao, D. M.; Cheng, L.; Liu, X. J.; Hu, Y. D.; Xu, X. H.; Liu, Z. H.; Zhang, L. P.; Wu, W.; Wang, S. L.; Shen, Y.; Li, G.; Wang, Y.; Zhao, S.; Li, C. L.; Tang, J.; Yu, H. H. “2,4-Diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors”, US Patent 9428508 B2, Date of Patent: 08/30/2016.

    18. 校登明,程靓,刘希杰,胡远东,许新合,刘志华,张立鹏,吴伟,王树龙,沈宇,李根,王银,赵胜,李舂龙,唐佳,于洪灏,“作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物”,中国专利,申请号:201280004821.1,申请日:2012年1月7日。

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