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程靓 研究员
国家优秀青年基金获得者 电话：+86-10-61943102 传真：+86-10-62554449 |
学术经历
2000–2004 北京师范大学，学士学位
2004–2009 中国科学院化学研究所，博士学位
2009–2011 合成研究员，凯美隆（北京）药业技术有限公司，北京赛林泰医药技术有限公司
2011–2014 美国哥伦比亚大学，博士后
2015–至今 中国科学院化学研究所，研究员
研究方向
化学生物学是一门利用外源的化学物质、化学方法或途径，在分子层面上对生命体系进行精准的修饰、调控和阐释的学科。作为化学生物学重要的研究方向之一，研究发展能够与RNA发生相互作用的化学分子，不仅可以用来作为研究核酸性质与功能的探针，还有可能被进一步开发，用来作为控制生物体运动与行为的活性物质。我们的研究兴趣是开发结构新颖、易于合成和修饰的有机分子化合物，进而发展针对RNA的特异性高级结构具有较高识别性能的小分子体系，同时开展具有生物活性的天然产物和重要的药物分子的合成研究。具体研究方向包括：
1. 基于RNA的化学生物学
2. 生物活性分子的合成方法学
Selected Work
1. Biomimetic Binding and Cleavage of RNA by Synthetic Deoxypolypeptides (DOPPs)
2. Tunneling in Base-Catalyzed Isomerization of GLA to DHA under Formose Conditions
3. Discovery and Development of FAK/Pyk2 Dual Inhibitor CT-707
4. Chemo- and Enantio-selective C-H Functionalization of Indole Derivatives
Selected Publications
1. Huang, H.-Y.; Cheng, L.*; Liu, J.-J.; Wang, D.; Liu, L.*; Li, C.-J.* "Transition-Metal-Free Alkynylation of 2-Oxindoles through Radical-Radical Coupling", J. Org. Chem. 2017, 82, 2656-2663.
2. Wei, F.; Cheng, L.*; Huang, H.-Y.; Liu, J.-J.; Wang, D.; Liu, L.* "Intermolecular Dearomative Oxidative Coupling of Indoles with Ketones and Sulfonylhydrazines Catalyzed by I2 for the Synthesis of [2,3]-Fused Indoline Tetrahydropyridazines", Sci. China Chem. 2016, 59, 1311-1316.
3. Kong, D.-L.; Cheng, L.*; Yue, T.; Wu, H.-R.; Feng, W.-C.; Wang, D.; Liu, L.* "Cobalt-Catalyzed Peroxidation of 2-Oxindoles with Hydroperoxides", J. Org. Chem. 2016, 81, 5337-5344.
4. Wu, H.-R.; Cheng, L.; Kong, D.-L.; Huang, H.-Y.; Gu, C.-L.; Liu, L.*; Wang, D.; Li, C.-J.* “FeCl3-mediated radical tandem reactions of 3-benzyl-2-oxindoles with styrene derivatives for the stereoselective synthesis of spirocyclohexene oxindoles”, Org. Lett. 2016, 18, 1382–1385.
5. Li, X.-D.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L.* “Metal-free allylation of electron-rich heteroaryl boronic acids with allylic alcohols”, Tetrahedron 2016, 72, 1873-1880.
6. Kong, D.-L.; Cheng, L.; Wu, H.; Li, Y.; Wang, D.; Liu, L.* “Metal-free yne-addition/1,4-aryl migration/decarboxylation cascade reaction of alkynoates with Csp3-H centers”, Org. Biomol. Chem. 2016, 14, 2210−2217.
7. Cheng, L.; Charles, D.*; Breslow, R.* “Evidence for tunneling in base-catalyzed isomerization of glyceraldehyde to dihydroxyacetone by hydride shift under formose conditions”, Proc. Natl. Acad. Sci. USA 2015, 112, 4218−4220.
8. Cheng, L.; Mahendran, A.; Gonzalez, R. L. Jr.*; Breslow, R.* “Deoxypolypeptides bind and cleave RNA”, Proc. Natl. Acad. Sci. USA 2014, 111, 7920–7924.
9. Cheng, L.; Abhilash, K. G.; Breslow, R.* “Binding and biomimetic cleavage of the RNA poly(U) by synthetic polyimidazoles”, Proc. Natl. Acad. Sci. USA 2012, 109, 12884−12887.
10. Cheng, L.; Liu, L.*; Li, C.; Jia, H.; Wang, D.; Chen, Y. J.* “Nucleophilic addition of regioselectively lithiated indoline with aldimines for the syntheses of 2- and 7-indolinyl methanamine derivatives”, Tetrahedron Lett. 2012, 53, 4004−4007.
11. Zhang, T.; Cheng, L.; Hameed, S.; Liu, L.*; Wang, D.; Chen, Y. J.* “Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea”, Chem. Commun. 2011, 47, 6644−6646.
12. Zhang, T.; Cheng, L.; Liu, L.*; Wang, D.; Chen, Y. J.* “Asymmetric organocatalytic N-nitroso-aldol reaction of oxindoles”, Tetrahedron: Asymmetry 2010, 21, 2800−2806.
13. Cheng, L.; Liu, L.*; Wang, D.; Chen, Y. J.* “Highly enantioselective and organocatalytic alpha-amination of 2-oxindoles”, Org. Lett. 2009, 11, 3874−3877.
14. Cheng, L.; Liu, L.*; Jia, H.; Wang, D.; Chen, Y. J.* “Enantioselective organocatalytic anti-Mannich-type reaction of N-unprotected 3-substituted 2-oxindoles with aromatic N-Ts-aldimines”, J. Org. Chem. 2009, 74, 4650−4653.
15. Cheng, L.; Liu, L.*; Sui, Y.; Wang, D.; Chen, Y. J.* “Highly diastereoselective reactions of 2-lithiated indoles with chiral N-tert-butanesulfinyl aldimines for the synthesis of chiral (2-indolyl) methanamine derivatives”, Tetrahedron: Asymmetry 2007, 18, 1833−1843.
16. 校登明，程靓，刘希杰，胡远东，许新合，刘志华，张立鹏，吴伟，王树龙，沈宇，李根，王银，赵胜，李舂龙，唐佳，于洪灏，“作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物”，中国专利，授权号：ZL 201110002776.3，公告日：2015年1月28日。
17. Xiao, D. M.; Cheng, L.; Liu, X. J.; Hu, Y. D.; Xu, X. H.; Liu, Z. H.; Zhang, L. P.; Wu, W.; Wang, S. L.; Shen, Y.; Li, G.; Wang, Y.; Zhao, S.; Li, C. L.; Tang, J.; Yu, H. H. “2,4-Diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors”, US Patent 9428508 B2, Date of Patent: 08/30/2016.
18. 校登明，程靓，刘希杰，胡远东，许新合，刘志华，张立鹏，吴伟，王树龙，沈宇，李根，王银，赵胜，李舂龙，唐佳，于洪灏，“作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物”，中国专利，申请号：201280004821.1，申请日：2012年1月7日。