化学所分子识别与功能实验室
学术带头人

       罗三中    研究员

       

        国家杰出青年基金获得者

        电话:86-10-62554446

        传真:86-10-62554449

        邮箱:luosz@iccas.ac.cn

        课题组主页:http://luosz.iccas.ac.cn

     

    学术经历

    2002-2005   中国科学院化学所博士学位

    2004-2005   美国俄亥俄州立大学访问学者

    2009-2009   美国斯坦福大学访问学者

    2005-2011   中国科学院化学研究所,先后任助理研究员、副研究员、课题组长

    2011-至今    中国科学院化学研究所,研究员

     

    荣誉与奖项

    2007   荣获北京市科技新星

    2008   中国化学会青年化学家奖

    2009   中科院卢嘉锡青年人才奖

    2010   获国家杰出青年基金

    2011   入选中科院创新促进会,任理事长(2011-2015)

    2012   Thieme Journal Award

    2012   Asian Core Program Lectureship

    2012   入选中组部青年拔尖人才计划

    2013   中科院北京分院“启明星”优秀人才

    2014   中国青年五四奖章

    2016   中国化学会手性青年化学奖

    2017   中国化学会物理有机化学青年奖

     

    研究方向

    化学反应活性和选择性的精巧控制、复杂分子快捷高效率的构造以及环境友好反应的设计开发是当前有机化学所面临的最具代表性的挑战。研究工作围绕上述挑战性难题,强调向自然学习,设计利用生物催化原理,发展新型催化体系和新反应。具体研究方向包括:

    1. 仿生小分子催化

    2. (不对称)超分子催化

    3. 催化体系物理有机研究

    4. 方法学导向天然产物全合成

     

    Selected Work

    1. Bio-inspired primary amine catalysis

    Synlett. 2012, 1575 (account), Acc. Chem. Res. 2015, 48, 986. (Account)

     

    2. Asymmetric Binary Acid Catalysis (ABC)

    Chem. Commun. 2013, 49, 847 (feature article)

     

    Selected Publications

    1. Zhou, H.; Wang, Y.; Zhang, L.; Cai, M.; Luo, S.* “Enantioselective Terminal Addition to Allenes by Dual Chiral Primary Amine/Palladium Catalysis” J. Am. Chem. Soc. 2017, 139, 3631-3634.

    2. Yang, Q.; Zhang, L.; Ye, C.; Luo, S.*; Wu, L.-Z.*; Tung, C.-H. “Visible-Light-Promoted Asymmetric Cross-Dehydrogenative Coupling of Tertiary Amines to Ketones by Synergistic Multiple Catalysis” Angew. Chem. Int. Ed. 2017, 56, 3694-3698.

    3. Qin, Y.; Zhu, L.; Luo, S.* “Organocatalysis Inert C-H Bond Functionalization” Chem. Rev. 2017, 117, 9433-9520.

    4. You, Y.; Zhang, L.; Luo, S.* “Reagent-controlled Enantioselectivity Switch for the Asymmetric Fluorination of b-ketocarbonyls by chiral primary amine catalysis” Chem. Sci. 2017, 8, 621-526.

    5. Zhu, Y.; Zhang, L.; Luo, S.* “Asymmetric Retro-Claisen Reaction by Chiral Primary Amine Catalysis” J. Am. Chem. Soc. 2016, 138, 3978-3981.

    6. Lv, J.; Zhang, Q.; Zhong, X.; Luo, S.* “Asymmetric Latent Carbocation Catalysis with Chiral Trityl Phosphate” J. Am. Chem. Soc. 2015, 137, 15576-15583.

    7. Zhou, H.; Zhang, L.; Xu, C.; Luo, S.* “Chiral Primary Amine/Palladium Dual Catalysis for Asymmetric Allylic Alkylation of b-Ketocarbonyl Compounds with Allylic Alcohols” Angew. Chem. Int. Ed. 2015, 54, 12645-12648.

    8. Zhang, L.; Fu, N.; Luo. S.* “Pushing the Limits of Aminocatalysis: Enantioselective Transformations of α-Branched β-Ketocarbonyls and Vinyl ketones by Chiral Primary Amines” Acc. Chem. Res. 2015, 48, 986-997.

    9. Zhang, Q.; Cui, X.*; Zhang, L.; Luo, S.*; Wang, H.; Wu. Y.* “Redox Tuning of a Direct Asymmetric Aldol Reaction” Angew. Chem. Int. Ed. 2015, 54, 5210-5213.

    10. Qin, Y.; Zhang, L.; Lv, J.; Luo, S.*; Cheng, J.-P. “Bio-inspired Organocatalytic Aerobic C-H Oxidation of Amines with an ortho-Quinone Catalyst” Org. Lett. 2015, 17, 1469-1472.

    11. Zhu, Y.; Zhang, L.; Luo, S.* “Asymmetric α-Photoalkylation of β-Ketocarbonyls by Primary Amine Catalysis: Facile Access to Acyclic All-Carbon Quaternary Stereocenters” J. Am. Chem. Soc., 2014, 136, 14642-14645.

    12. Xu, C.; Zhang, L.; Luo, S.* “Merging Aerobic Oxidation and Enamine Catalysis in the Asymmetric α-Amination of β-Ketocarbonyls Using N-Hydroxycarbamates as Nitrogen Sources” Angew. Chem. Int. Ed., 2014, 53, 4149-4153.

    13. Lv, J.; Zhang, L.; Luo, S.*; Cheng, J.-P. “Diastereoselectively Switchable Enantioselective [4+2] cycloadditions with Simple Olefins via Asymmetric Binary Acid Catalysis” Angew. Chem. Int. Ed. 2013, 52, 9786-9790.

    14. Lv, J.; Zhang, L.; Zhou, Y.; Nie, Z.; Luo, S.*; Cheng, J.-P. “Asymmetric binary acid catalysis: a regioselectivity switch between enantioselective 1,2- and 1,4-addition through different counteranions of In(III)” Angew. Chem. Int. Ed. 2011, 50, 6610-6614.

    15. Fu, N.; Zhang, L.; Li, J.; Luo, S.*; Cheng, J.-P. “Chiral primary amine catalyzed enantioselective protonation via an enamine intermediate” Angew. Chem. Int. Ed. 2011, 50, 11451.

    16. Hu, S.; Li, J.; Xiang, J.; Pan, J.; Luo, S. Z.*, Cheng, J.-P.* “Asymmetric supramolecular primary amine catalysis in aqueous buffer: Connections of selective recognition and asymmetric catalysis” J. Am. Chem. Soc. 2010, 132, 7216-7228. (Highlighted by synfact)

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