化学所分子识别与功能实验室
学术带头人

       范青华  研究员

       

        国家杰出青年基金获得者

        电话:86-10-62554472

        传真:86-10-62554449

        邮箱:fanqh@iccas.ac.cn

        课题组主页:http://fanqh.iccas.ac.cn/

     

    学术经历

    1985.9-1989.7   湘潭大学化学系  本科

    1989.9-1992.7   中国科学院化学研究所 硕士研究生

    1995.2-1998.2   香港理工大学应用生物与化学科技系 博士研究生

    1992.8-1998.4   中国科学院化学研究所,先后任研究实习员和助理研究员

    1998.4-2003.4   中国科学院化学研究所,副研究员和课题组长

    2003.4-至  今     中国科学院化学研究所,研究员

     

    荣誉与奖励

    2003   获国家杰出青年基金

    2005   国家自然科学二等奖(排名第二)

    2008   获中国科学院“百人计划”资助

    2009   获“国务院政府特殊津贴”

    2012   Asian Core Program Lectureship Award

    2013   入选国家百千万人才工程

    2014   基金委创新研究群体负责人

     

    研究方向

    作为生命过程的重要化学基础,识别、组装和催化一直是有机化学研究的前沿和核心内容。研究工作一方面针对手性催化剂的选择性、催化效率和催化剂的分离回收等核心科学问题,发展高效、实用和环境友好的不对称催化反应,以及可方便分离回收的手性催化剂新体系;另一方面基于树状大分子结构的特异性,发展新型的功能有机分子,以及他们在不对称催化、自组装及功能材料领域中的应用。具体研究方向包括:

    1. 不对称催化

    2. 环境友好的催化反应

    3. 生物活性杂环化合物的合成

    4. 功能树状分子的设计合成及组装

     

    Selected Work

    1. Asymmetric hydrogenation of heteroaromatic compounds and imines

     

    Top. Curr. Chem. 2014, 343, 145-190 (review).

     

    2. Asymmetric hydrogenation in the core of dendrimers

          Acc. Chem. Res. 2014, 47, 2894-2906.

     

    3. Versatile dendritic organogelators and their applications

          

    Chem. Asian J. 2014, 9, 1724-1750 (review).

     

    Selected Publications

    1. Miao,T.; Tian, Z.-Y.;  He, Y.-M.; Chen, F.; Chen, Y.; Yu, Z.-X.*; Fan, Q.-H.* “Asymmetric hydrogenation of in situ generated isochromenylium intermediates by copper/ruthenium tandem catalysis” Angew. Chem. Int. Ed. 2017, 56, 4135–4139.

    2. Yang, Z.; Chen, F.*; He, Y.-M.; Yang, N.; Fan, Q.-H.* “Highly enantioselective synthesis of indolines: Asymmetric hydrogenation at ambient temperature and pressure with cationic ruthenium diamine catalysts” Angew. Chem. Int. Ed. 2016, 55, 13863–13866.

    3. Ma, W.; Zhang, J.; Xu, C.; Chen, F.; He, Y.-M.; Fan, Q.-H.* “Highly enantioselective direct synthesis of endocyclic vicinal diamines by chiral Ru(diamine)-catalyzed hydrogenation of 2,2’-bisquinoline derivatives”, Angew. Chem. Int. Ed. 2016, 55, 12891–12894.

    4. Zhang, J.; Chen, F.; He, Y.-M.; Fan, Q.-H.* “Asymmetric ruthenium-catalyzed hydrogenation of 2,6-disubstituted 1,5-naphthyridines: Access to chiral 1,5-diaza-cis-decalins” Angew. Chem. Int. Ed. 2015, 54, 4622–4625.

    5. Ouyang, G.-H.; He, Y.-M.; Li, Y.; Xiang, J.; Fan, Q.-H.* “Cation-triggered switchable asymmetric catalysis with chiral aza-CrownPhos” Angew. Chem. Int. Ed. 2015, 54, 4334–4337.

    6. Chen, F.; Ding, Z.-Y.; He, Y.-M.; Fan, Q.-H.* “Synthesis of optically active 1,2,3,4-tetrahydroquinolines via asymmetric hydrogenation using iridium-diamine catalyst”, Org. Synth. 2015, 92, 213–226.

    7. He, Y.-M.; Feng, Y.; Fan, Q.-H.* “Asymmetric hydrogenation in the core of dendrimers” Acc. Chem. Res. 2014, 47, 2894−2906.

    8. Zhao, Z.; Chen, C.; Dong, Y.; Yang, Z.; Fan, Q.-H.*; Liu, D.* “Thermally triggered frame-guided assembly” Angew. Chem. Int. Ed. 2014, 53, 13468–13470.

    9. Wang, T.; Chen, F.; Qin, J.; He, Y.-M.; Fan, Q.-H.* “Asymmetric ruthenium-catalyzed hydrogenation of 2- and 2,9-substituted 1,10-phenanthrolines” Angew. Chem. Int. Ed. 2013, 51, 7172–7176.

    10. Ding, Z.; Chen, F.; Qin, J.; He, Y.-M.; Fan, Q.-H.* “Asymmetric hydrogenation of 2,4-disubstituted 1,5-benzodiazepines using cationic ruthenium diamine catalysts: An unusual achiral counteranion induced reversal of enantioselectivity” Angew. Chem. Int. Ed. 2012, 51, 5706–5710.

    11. Wang, T.; Zhuo, L.; Li, Z.; Chen, F.; Ding, Z.; He, Y.-M.; Fan, Q.-H.*; Xiang, J.; Yu, Z.-X.*; Chan, A. S. C. “Highly enantioselective hydrogenation of quinolines using phosphine-free chiral cationic ruthenium catalysts: Scope, mechanism, and origin of enantioselectivity” J. Am. Chem. Soc. 2011, 133, 9878–9891.

    12. Chen, Q.; Feng, Y.; Zhang, D.*; Zhang, G.; Fan, Q.-H.*; Sun, S.; Zhu, D. “Light-triggered self-assembly of a spiropyran-functionalized dendron into nano-/micrometer-sized particles and photoresponsive organogel with switchable fluorescence” Adv. Funct. Mater. 2010, 20, 36–42.

    13. Feng, Y.; Liu, Z.; Liu, J.; He, Y.-M.*; Zheng, Q.; Fan, Q.-H.* “Peripherally dimethyl isophthalate- functionalized poly(benzyl ether) dendrons: A new kind of unprecedented highly efficient organogelators” J. Am. Chem. Soc. 2009, 131, 7950–7951.

    14. Tang, W.; Xu, L.*; Fan, Q.-H.*; Wang, J.; Fan, B.; Zhou, Z.; Lam, K.-H.; Chan, A. S. C.* “Asymmetric hydrogenation of quinoxalines with diphosphinite ligands: A practical synthesis of enantioenriched substituted tetrahydroquinoxalines” Angew. Chem. Int. Ed. 2009, 48, 9135–9238.

    15. Zhou, H.; Li, Z.; Wang, Z.; Wang, T.; Xu, L.; He, Y.-M.; Fan, Q.-H.*; Pan, J.; Gu, L.; Chan, A. S. C.* “Hydrogenation of quinolines using a recyclable phosphine-free chiral cationic ruthenium catalyst: Enhancement of catalyst stability and selectivity in an ionic liquid ” Angew. Chem. Int. Ed. 2008, 47, 8464–8467.

    16. Wang, Z.; Deng, G.-J.; Li, Y.; He, Y.-M.; Tang, W.-J.; Fan, Q.-H.* “Enantioselective hydrogenation of quinolines catalyzed by Ir(BINAP)-cored dendrimers: Dramatic enhancement of catalytic activity” Org. Lett. 2007, 9, 1243–1246.

    17. Fan, Q.-H.; Li, Y.-M.*; Chen, A. S. C.* “Recoverable catalysts for asymmetric organic synthesis” Chem. Rev. 2002, 102, 3385–3466.

    18. 丁奎岭,范青华 主编,《不对称催化新概念与新方法》,化学工业出版社,2008年 (Asymmetric Catalysis: New Concepts and Methods, Editors: Kuiling Ding and Qing-Hua Fan, China Chemical Industry Press, 2008).

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