学术经历

2000–2004   北京师范大学，学士学位

2004–2009   中国科学院化学研究所，博士学位

2009–2011   合成研究员，凯美隆（北京）药业技术有限公司，北京赛林泰医药技术有限公司

2011–2014   美国哥伦比亚大学，博士后

2015–至今    中国科学院化学研究所，研究员

研究方向

RNA修饰的标记、鉴定与调控是当前生命科学的研究前沿，但相应化学工具的缺乏阻碍了其基础研究和生物医学的发展。我们围绕这些关键科学问题开展研究，取得了以下进展：1）开发了靶向RNA修饰的新型生物正交化学和探针分子，实现了对细胞和植物中RNA修饰的直接化学干预；2）建立了对细胞转录组中RNA修饰的时空分辨调控新方法和单碱基测序新技术；3）在活体水平实现了功能性修饰RNA的选择性激活。具体研究方向包括：

1）RNA表观修饰的精准化学干预（Chemical Strategies to Modulate and Manipulate RNA Epigenetic Modifications, Acc. Chem. Res. 2025）

2）功能性RNA的化学改造与应用（Topology-Engineered Guide RNAs for Programmable Control of CRISPR/Cas Activity, Angew. Chem. Int. Ed. 2025）

Selected Work

Selected Publications

1.     Chen, W.-D.; Liu, L.; Cheng, L.* "Functionally Tunable Star-Shaped Multivalent crRNAs for Photocontrol CRISPR/Cas Editing", Angew. Chem. Int. Ed. 2025, DOI: 10.1002/anie.202506527.

2.     Cheng, L.* "Chemical Strategies to Modulate and Manipulate RNA Epigenetic Modifications", Acc. Chem. Res. 2025, DOI: 10.1021/acs.accounts.4c00844.

3.     He, Y.-M.; Burkard, A.; Wu, C.-S.; Jin, X.-Y.; Liu, L.; Helm, M.*; Cheng, L.* "A Direct Chemical Repair of Etheno-Type RNA Damages", Angew. Chem. Int. Ed. 2025, 64, e202415417.

4.     Wu, C.-S.; Sun, X.; Liu, L.; Cheng, L.* "A Live-Cell Epigenome Manipulation by Photo-Stimuli-Responsive Histone Methyltransferase Inhibitor", Adv. Sci. 2024, 11, 2404608.

5.     Xie, L.-J.; Cheng, H.-P.; Chen, M.-Y.; Wang, X.; Liu, L.; Yuan, B.-F.; Cheng, L.* "A Bioorthogonal Post-Modification of N6-Isopentenyl Adenosine i6A RNA in live cells", CCS Chem. 2024, 6, 2241–2253. 

6.     Sun, Y.-J.; Chen, W.-D.; Liu, J.; Li, J.-J.; Zhang, Y.; Cai, W.-Q.; Liu, L.; Tang, X.-J.;* Hou, J.;* Wang, M.;* Cheng, L.* "A Conformational Restriction Strategy for the Control of CRISPR/Cas Gene Editing with Photoactivatable Guide RNAs", Angew. Chem. Int. Ed. 2023, 62, e202212413.

7.     Jin, X.-Y.; Huang, Z.-R.; Xie, L.-J.; Liu, L.; Han, D.-L.;* Cheng, L.* "Photo-Facilitated Detection and Sequencing of 5-Formylcytidine RNA", Angew. Chem. Int. Ed. 2022, 61, e202210652. (VIP Article)

8.     Lan, L.; Sun, Y.-J.; Jin, X.-Y.; Xie, L.-J.; Liu, L.; Cheng, L.* "A Light-controllable Chemical Modulation of m6A RNA Methylation", Angew. Chem. Int. Ed. 2021, 60, 18116-18121. 

9.     Cheng, H.-P.; Yang, X.-H.; Lan, L.; Xie, L.-J.; Chen, C.; Liu, C.; Chu, J.; Li, Z.-Y.; Zhang, T.-Q.;* Luo, D.-Q.;* Cheng, L.* "Chemical Deprenylation of N6-Isopentenyladenosine (i6A) RNA", Angew. Chem. Int. Ed. 2020, 59, 10645-10650.

10.   Xie, L.-J.;# Yang, X.-T.;# Wang, R.-L.; Cheng, H.-P.; Li, Z.-Y.; Liu, L.; Mao, L. Q.; Wang, M.*; Cheng, L.* "Identification of Flavin Mononucleotide as Cell-Active Artificial N6-Methyladenosine RNA Demethylase", Angew. Chem. Int. Ed. 2019, 58, 5028-5032.