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范青华 研究员
国家杰出青年基金获得者 电话：86-10-62554472 传真：86-10-62554449 |
学术经历
1985.9-1989.7 湘潭大学化学系 本科
1989.9-1992.7 中国科学院化学研究所 硕士研究生
1995.2-1998.2 香港理工大学应用生物与化学科技系 博士研究生
1992.8-1998.4 中国科学院化学研究所，先后任研究实习员和助理研究员
1998.4-2003.4 中国科学院化学研究所，副研究员和课题组长
2003.4-至 今 中国科学院化学研究所，研究员
荣誉与奖励
2003 获国家杰出青年基金
2005 国家自然科学二等奖（排名第二）
2009 获“国务院政府特殊津贴”
2012 Asian Core Program Lectureship Award
2013 入选国家百千万人才工程
2014 基金委创新研究群体负责人
研究方向
作为生命过程的重要化学基础，识别、组装和催化一直是有机化学研究的前沿和核心内容。研究工作一方面针对手性催化剂的选择性、催化效率和催化剂的分离回收等核心科学问题，发展高效、实用和环境友好的不对称催化反应，以及可方便分离回收的手性催化剂新体系；另一方面基于树状大分子结构的特异性，发展新型的功能有机分子，以及他们在不对称催化、自组装及功能材料领域中的应用。具体研究方向包括：
1. 不对称催化
2. 环境友好的催化反应
3. 生物活性杂环化合物的合成
4. 功能树状分子的设计合成及组装
Selected Work
1. Asymmetric hydrogenation of heteroaromatic compounds and imines
Top. Curr. Chem. 2014, 343, 145-190 (review).
2. Asymmetric hydrogenation in the core of dendrimers
Acc. Chem. Res. 2014, 47, 2894-2906.
3. Versatile dendritic organogelators and their applications
Chem. Asian J. 2014, 9, 1724-1750 (review).
Selected Publications
1. Miao,T.; Tian, Z.-Y.; He, Y.-M.; Chen, F.; Chen, Y.; Yu, Z.-X.*; Fan, Q.-H.* “Asymmetric hydrogenation of in situ generated isochromenylium intermediates by copper/ruthenium tandem catalysis” Angew. Chem. Int. Ed. 2017, 56, 4135–4139.
2. Yang, Z.; Chen, F.*; He, Y.-M.; Yang, N.; Fan, Q.-H.* “Highly enantioselective synthesis of indolines: Asymmetric hydrogenation at ambient temperature and pressure with cationic ruthenium diamine catalysts” Angew. Chem. Int. Ed. 2016, 55, 13863–13866.
3. Ma, W.; Zhang, J.; Xu, C.; Chen, F.; He, Y.-M.; Fan, Q.-H.* “Highly enantioselective direct synthesis of endocyclic vicinal diamines by chiral Ru(diamine)-catalyzed hydrogenation of 2,2’-bisquinoline derivatives”, Angew. Chem. Int. Ed. 2016, 55, 12891–12894.
4. Zhang, J.; Chen, F.; He, Y.-M.; Fan, Q.-H.* “Asymmetric ruthenium-catalyzed hydrogenation of 2,6-disubstituted 1,5-naphthyridines: Access to chiral 1,5-diaza-cis-decalins” Angew. Chem. Int. Ed. 2015, 54, 4622–4625.
5. Ouyang, G.-H.; He, Y.-M.; Li, Y.; Xiang, J.; Fan, Q.-H.* “Cation-triggered switchable asymmetric catalysis with chiral aza-CrownPhos” Angew. Chem. Int. Ed. 2015, 54, 4334–4337.
6. Chen, F.; Ding, Z.-Y.; He, Y.-M.; Fan, Q.-H.* “Synthesis of optically active 1,2,3,4-tetrahydroquinolines via asymmetric hydrogenation using iridium-diamine catalyst”, Org. Synth. 2015, 92, 213–226.
7. He, Y.-M.; Feng, Y.; Fan, Q.-H.* “Asymmetric hydrogenation in the core of dendrimers” Acc. Chem. Res. 2014, 47, 2894−2906.
8. Zhao, Z.; Chen, C.; Dong, Y.; Yang, Z.; Fan, Q.-H.*; Liu, D.* “Thermally triggered frame-guided assembly” Angew. Chem. Int. Ed. 2014, 53, 13468–13470.
9. Wang, T.; Chen, F.; Qin, J.; He, Y.-M.; Fan, Q.-H.* “Asymmetric ruthenium-catalyzed hydrogenation of 2- and 2,9-substituted 1,10-phenanthrolines” Angew. Chem. Int. Ed. 2013, 51, 7172–7176.
10. Ding, Z.; Chen, F.; Qin, J.; He, Y.-M.; Fan, Q.-H.* “Asymmetric hydrogenation of 2,4-disubstituted 1,5-benzodiazepines using cationic ruthenium diamine catalysts: An unusual achiral counteranion induced reversal of enantioselectivity” Angew. Chem. Int. Ed. 2012, 51, 5706–5710.
11. Wang, T.; Zhuo, L.; Li, Z.; Chen, F.; Ding, Z.; He, Y.-M.; Fan, Q.-H.*; Xiang, J.; Yu, Z.-X.*; Chan, A. S. C. “Highly enantioselective hydrogenation of quinolines using phosphine-free chiral cationic ruthenium catalysts: Scope, mechanism, and origin of enantioselectivity” J. Am. Chem. Soc. 2011, 133, 9878–9891.
12. Chen, Q.; Feng, Y.; Zhang, D.*; Zhang, G.; Fan, Q.-H.*; Sun, S.; Zhu, D. “Light-triggered self-assembly of a spiropyran-functionalized dendron into nano-/micrometer-sized particles and photoresponsive organogel with switchable fluorescence” Adv. Funct. Mater. 2010, 20, 36–42.
13. Feng, Y.; Liu, Z.; Liu, J.; He, Y.-M.*; Zheng, Q.; Fan, Q.-H.* “Peripherally dimethyl isophthalate- functionalized poly(benzyl ether) dendrons: A new kind of unprecedented highly efficient organogelators” J. Am. Chem. Soc. 2009, 131, 7950–7951.
14. Tang, W.; Xu, L.*; Fan, Q.-H.*; Wang, J.; Fan, B.; Zhou, Z.; Lam, K.-H.; Chan, A. S. C.* “Asymmetric hydrogenation of quinoxalines with diphosphinite ligands: A practical synthesis of enantioenriched substituted tetrahydroquinoxalines” Angew. Chem. Int. Ed. 2009, 48, 9135–9238.
15. Zhou, H.; Li, Z.; Wang, Z.; Wang, T.; Xu, L.; He, Y.-M.; Fan, Q.-H.*; Pan, J.; Gu, L.; Chan, A. S. C.* “Hydrogenation of quinolines using a recyclable phosphine-free chiral cationic ruthenium catalyst: Enhancement of catalyst stability and selectivity in an ionic liquid ” Angew. Chem. Int. Ed. 2008, 47, 8464–8467.
16. Wang, Z.; Deng, G.-J.; Li, Y.; He, Y.-M.; Tang, W.-J.; Fan, Q.-H.* “Enantioselective hydrogenation of quinolines catalyzed by Ir(BINAP)-cored dendrimers: Dramatic enhancement of catalytic activity” Org. Lett. 2007, 9, 1243–1246.
17. Fan, Q.-H.; Li, Y.-M.*; Chen, A. S. C.* “Recoverable catalysts for asymmetric organic synthesis” Chem. Rev. 2002, 102, 3385–3466.
18. 丁奎岭，范青华 主编，《不对称催化新概念与新方法》，化学工业出版社，2008年 (Asymmetric Catalysis: New Concepts and Methods, Editors: Kuiling Ding and Qing-Hua Fan, China Chemical Industry Press, 2008).