化学所分子识别与功能实验室
学术带头人

       杜海峰  研究员

       

        国家杰出青年基金获得者

        电话:86-10-62652117

        传真:86-10-62554449

        邮箱:haifengdu@iccas.ac.cn

        课题组主页:http://haifengdu.iccas.ac.cn/

     

    学术经历

    1994-1998   南开大学,学士学位

    1998-2001   南开大学与中国科学院上海有机化学研究所联合培养,硕士学位

    2001-2004   中国科学院上海有机化学研究所,博士学位

    2004-2008   美国科罗拉多州立大学,博士后

    2008-至今   中国科学院化学研究所,研究员

     

    荣誉与奖励

    2018   国家自然科学基金委员会“杰出青年科学基金”

    2017   第四届中国均相催化青年奖

    2015   Asian Core Program Lectureship Award

    2012   国家自然科学基金委员会“优秀青年科学基金”

     

    研究方向

    不对称催化是目前获得光学活性化合物最有效的手段,而手性配体和催化剂是不对称催化领域永恒的主题。我们的研究兴趣是开发结构新颖、易于合成、易于修饰、性能优良的手性配体和催化剂,发展高效不对称催化体系。研究方向如下:

    1. 不对称催化

    2. 选择性合成

    3. 重要手性化合物合成

     

    Selected Work

    1. Chiral olefin ligands

         

     

    2. Metal-free Hydrogenation with Frustrated Lewis Pairs

         

     

    Selected Publications

    1. Li, S.; Meng, W.; Du, H.* “Asymmetric transfer hydrogenations of 2,3-disubstituted quinoxalines with ammonia borane” Org. Lett. 201719, 2604-2606.

    2. Li, S.; Li, G.; Meng, W.*; Du, H.* “A frustrated Lewis pair catalyzed asymmetric transfer hydrogenation of imines using ammonia borane” J. Am. Chem. Soc. 2016, 138, 12956-12962.

    3. Ren, X.; Du, H.* “Chiral frustrated Lewis pairs catalyzed highly enantioselective hydrosilylations of 1,2-dicarbonyl compoundsJ. Am. Soc. Chem. 2016,138, 810-813.

    4. Zhang, Z.; Du, H.* “Enantioselective metal-free hydrogenations of disubstituted quinolinesOrg. Lett. 2015, 17, 6266-6269.

    5. Zhang, Z.; Du, H.* “A highly cis-selective and enantioselective metal-free hydrogenation of 2,3-disubstituted quinoxalines” Angew. Chem. Int. Ed. 2015, 54, 623-626.

    6. Zhang, Z. H.; Du, H. F.* “Cis-selective and highly enantioselective hydrogenation of 2,3,4-trisubstituted quinolines” Org. Lett. 2015, 17, 2816-2819.

    7. Ren, X.; Li, G.; Wei, S.; Du, H.* “Facile development of chiral alkenylboranes from chiral diynes for asymmetric hydrogenation of silyl enol ethers” Org. Lett. 2015, 17, 990-993.

    8. Liu, Y.; Hu, L.; Chen, H.;* Du, H.* “An alkene-promoted borane-catalyzed highly stereoselective hydrogenation of alkynes to give Z- and E-alkenes" Chem. Eur. J. 2015, 21, 3495-3501.

    9. Zhu, X.; Du, H.* “A highly stereoselective metal-free hydrogenation of diimines for the synthesis of cis-vicinal diamines” Org. Lett. 2015, 17, 3106-3109.

    10. Wei, S. M.; Du, H. F.* “A highly enantioselective hydrogenation of silyl enol ethers catalyzed by chiral frustrated Lewis pairs” J. Am. Chem. Soc. 2014, 136, 12261−12264.

    11. Liu, Y.; Du, H.* “Metal-free borane-catalyzed highly stereoselective hydrogenation of pyridines” J. Am. Chem. Soc. 2013, 135, 12968−12971.

    12. Liu, Y.; Du, H.* “Chiral dienes as “ligands” for borane-catalyzed metal-free asymmetric hydrogenation of imines” J. Am. Chem. Soc. 2013, 135, 6810-6813.

    13. Feng, X.; Nie, Y.; Yang, J.*; Du, H.* “Rh(I)-catalyzed asymmetric 1,2-addition to α-diketones with chiral sulfur-alkene hybrid ligands” Org. Lett. 2012, 14, 624-627.

    14. Feng, X.; Wang, Y.; Wei, B.; Yang, J.;* Du, H.* “Simple N-sulfinyl-based chiral sulfur-olefin ligands for rhodium-catalyzed asymmetric 1,4-additions” Org. Lett. 2011, 13, 3300-3303.

    15. Cao, Z.; Liu, Y.; Liu, Z.; Feng, X.; Zhuang, M.; Du, H.* “Pd-catalyzed asymmetric allylic alkylation of indoles by chiral terminal-alkene-phosphine hybrid ligands” Org. Lett. 2011, 13, 2164-2167.

    16. Wang, Y.; Hu, X.; Du, H.* “Vicinal-diamine-based chiral chain dienes as ligands for rhodium(I)-catalyzed highly enantioselective conjugated additions” Org. Lett. 2010, 12, 5482-5485.

    17. Hu, X.; Zhuang, M.; Cao, Z.; Du, H.* “Simple chiral chain dienes as ligands for Rh(I)-catalyzed conjugated additions” Org. Lett. 2009, 11, 4744-4747.

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