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杜海峰 研究员
国家杰出青年基金获得者 电话:86-10-62652117 传真:86-10-62554449 邮箱:haifengdu@iccas.ac.cn |
学术经历
1994-1998 南开大学,学士学位
1998-2001 南开大学与中国科学院上海有机化学研究所联合培养,硕士学位
2001-2004 中国科学院上海有机化学研究所,博士学位
2004-2008 美国科罗拉多州立大学,博士后
2008-至今 中国科学院化学研究所,研究员
荣誉与奖励
2018 国家自然科学基金委员会“杰出青年科学基金”
2017 第四届中国均相催化青年奖
2015 Asian Core Program Lectureship Award
2012 国家自然科学基金委员会“优秀青年科学基金”
研究方向
不对称催化是目前获得光学活性化合物最有效的手段,而手性配体和催化剂是不对称催化领域永恒的主题。我们的研究兴趣是开发结构新颖、易于合成、易于修饰、性能优良的手性配体和催化剂,发展高效不对称催化体系。研究方向如下:
1. 不对称催化
2. 选择性合成
3. 重要手性化合物合成
Selected Work
1. Chiral olefin ligands
2. Metal-free Hydrogenation with Frustrated Lewis Pairs
Selected Publications
1. Li, S.; Meng, W.; Du, H.* “Asymmetric transfer hydrogenations of 2,3-disubstituted quinoxalines with ammonia borane” Org. Lett. 2017, 19, 2604-2606.
2. Li, S.; Li, G.; Meng, W.*; Du, H.* “A frustrated Lewis pair catalyzed asymmetric transfer hydrogenation of imines using ammonia borane” J. Am. Chem. Soc. 2016, 138, 12956-12962.
3. Ren, X.; Du, H.* “Chiral frustrated Lewis pairs catalyzed highly enantioselective hydrosilylations of 1,2-dicarbonyl compounds” J. Am. Soc. Chem. 2016,138, 810-813.
4. Zhang, Z.; Du, H.* “Enantioselective metal-free hydrogenations of disubstituted quinolines” Org. Lett. 2015, 17, 6266-6269.
5. Zhang, Z.; Du, H.* “A highly cis-selective and enantioselective metal-free hydrogenation of 2,3-disubstituted quinoxalines” Angew. Chem. Int. Ed. 2015, 54, 623-626.
6. Zhang, Z. H.; Du, H. F.* “Cis-selective and highly enantioselective hydrogenation of 2,3,4-trisubstituted quinolines” Org. Lett. 2015, 17, 2816-2819.
7. Ren, X.; Li, G.; Wei, S.; Du, H.* “Facile development of chiral alkenylboranes from chiral diynes for asymmetric hydrogenation of silyl enol ethers” Org. Lett. 2015, 17, 990-993.
8. Liu, Y.; Hu, L.; Chen, H.;* Du, H.* “An alkene-promoted borane-catalyzed highly stereoselective hydrogenation of alkynes to give Z- and E-alkenes" Chem. Eur. J. 2015, 21, 3495-3501.
9. Zhu, X.; Du, H.* “A highly stereoselective metal-free hydrogenation of diimines for the synthesis of cis-vicinal diamines” Org. Lett. 2015, 17, 3106-3109.
10. Wei, S. M.; Du, H. F.* “A highly enantioselective hydrogenation of silyl enol ethers catalyzed by chiral frustrated Lewis pairs” J. Am. Chem. Soc. 2014, 136, 12261−12264.
11. Liu, Y.; Du, H.* “Metal-free borane-catalyzed highly stereoselective hydrogenation of pyridines” J. Am. Chem. Soc. 2013, 135, 12968−12971.
12. Liu, Y.; Du, H.* “Chiral dienes as “ligands” for borane-catalyzed metal-free asymmetric hydrogenation of imines” J. Am. Chem. Soc. 2013, 135, 6810-6813.
13. Feng, X.; Nie, Y.; Yang, J.*; Du, H.* “Rh(I)-catalyzed asymmetric 1,2-addition to α-diketones with chiral sulfur-alkene hybrid ligands” Org. Lett. 2012, 14, 624-627.
14. Feng, X.; Wang, Y.; Wei, B.; Yang, J.;* Du, H.* “Simple N-sulfinyl-based chiral sulfur-olefin ligands for rhodium-catalyzed asymmetric 1,4-additions” Org. Lett. 2011, 13, 3300-3303.
15. Cao, Z.; Liu, Y.; Liu, Z.; Feng, X.; Zhuang, M.; Du, H.* “Pd-catalyzed asymmetric allylic alkylation of indoles by chiral terminal-alkene-phosphine hybrid ligands” Org. Lett. 2011, 13, 2164-2167.
16. Wang, Y.; Hu, X.; Du, H.* “Vicinal-diamine-based chiral chain dienes as ligands for rhodium(I)-catalyzed highly enantioselective conjugated additions” Org. Lett. 2010, 12, 5482-5485.
17. Hu, X.; Zhuang, M.; Cao, Z.; Du, H.* “Simple chiral chain dienes as ligands for Rh(I)-catalyzed conjugated additions” Org. Lett. 2009, 11, 4744-4747.