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郝伟 研究员
电话：86-10-82629302 传真：86-10-62554449
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学术经历
2006–2010 江苏大学，学士学位
2011–2016 北京大学，博士学位 (导师：席振峰 教授、张文雄 教授)
2016–2017 美国康奈尔大学，博士后 （导师：林松 教授）
2018–2021 美国Scripps研究所，博士后 （导师：Prof. Donna G. Blackmond）
2021–2022 北京大学，研究助理 （导师：张文雄 教授）
2022–至今 中国科学院化学研究所，研究员
荣誉与奖项
2022 Organic Division Horizon Prize: Robert Robinson Award in Synthetic Organic Chemistry，英国皇家化学会（集体奖）
2021 Green Chemistry Challenge Award，美国环保署（集体奖）
2016 优秀博士论文，北京大学
2015 国家奖学金
2014 陶氏化学可持续发展创新二等奖
2014 北京大学光华奖学金
2014 北京大学三好学生
2010 江苏大学优秀毕业生
研究方向
机理研究是化学基础研究的重要方向。结合物理有机化学和金属有机化学，从反应动力学角度研究反应过程和反应机理，从金属配合物角度研究活性催化物种、催化剂与底物的作用方式，揭示反应的本质与规律，进而发现新催化体系和新反应，将是未来的化学发展的重要趋势。具体研究方向包括：
1. 基于反应动力学研究反应机理
2. 机理导向的不对称催化新方法发展
Selected Work
1. Rh-Catalyzed Enantioselective Hydrogenation of 2‑Pyridyl-Substituted Alkenes
2. Probing Catalyst Speciation
3. Radical Redox Relay Catalysis
4. Reductive Elimination from Alkylpalladium Halides Containing syn-b-Hydrogen Atoms
Selected Publications
1. Hao, W.; Joe, C.; Darù, A.; Ayers, S.; Ramirez, A. Sandhu, B.; Daley, R. A.; Chen, J. S.; Schmidt, M. A.; Blackmond, D. G. Kinetic and Thermodynamic Considerations in the Rh-Catalyzed Enantioselective Hydrogenation of 2-Pyridyl Substituted Alkenes. ACS Catal. 2022, 12, 5961-5969.
2. Hao, W.; Joe, C.; Ayers, S.; Darù, A.; Daley, R. A.; Domanski, M.; Chen, J. S.; Schmidt, M. A.; Blackmond, D. G. Ru-Catalyzed Enantioselective Hydrogenation of 2-Pyridyl Substituted Alkenes and Substrate-Mediated H/D Exchange. ACS Catal. 2022, 12, 1150-1160.
3. Hao, W.; Bay, K. L.; Harris, C. F.; King, D. S.; Guzei, I. A.; Aristov, M.; Zhuang, Z.; Plata, R. E.; Hill, D. E.; Houk, K. N.; Berry, J. F.; Yu, J.-Q.; Blackmond, D. G. Probing Catalyst Speciation in Pd-MPAAM-Catalyzed Enantioselective C(sp3)-H Arylation: Catalyst Improvement via Destabilization of Off-Cycle Species. ACS Catal. 2021, 11, 11040-11048.
4. Hao, W.; Harenberg, J. H.; Wu, X.; MacMillan, N. S.; Lin, S. Diastereo- and Enantioselective Formal [3+2] Cycloaddition of Cyclopropyl Ketones and Alkenes via Ti-Catalyzed Radical Redox Relay. J. Am. Chem. Soc. 2018, 140, 3514-3517.
5. Hao, W.; Wu, X.; Sun, J. Z.; Siu, J. C.; MacMillan, S. N.; Lin, S. Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N‑Acylaziridines and Alkenes. J. Am. Chem. Soc. 2017, 139, 12141-12144.
6. Hao, W.; Wei, J.; Geng, W.; Zhang, W.-X.; Xi, Z. Transfer of Aryl Halide to Alkyl Halide: Reductive Elimination of Alkylhalide from Alkylpalladium Halide Containing syn-b-Hydrogens. Angew. Chem. Int. Ed. 2014, 53, 14533-14537.
7. Hao, W.; § Wei, J.; § Chi, Y.; Walsh, P. J.; Xi, Z. A DFT Study on Conversion of Aryl Iodides to Alkyl Iodides: Reductive Elimination of R–I from Alkylpalladium Iodide Complexes with Assessable b-Hydrogens. Chem. Eur. J. 2016, 22, 3422-3429.
8. Hao, W.; Wang, H.; Ye, Q.; Zhang, W.-X.; Xi, Z. Cyclopentadiene-Phosphine/Palladium Catalyzed Synthesis of Indolizines from pyrrole and alkenyl or aryl dibromides. Org. Lett. 2015, 17, 5674-5677.
9. Hao, W.; Wang, H.; Walsh, P. J.; Xi, Z. Combining Pd (π-allyl) Cp and PPh3 as a Unique Catalyst for Efficient Synthesis of Alkyliodo Indoles via C (sp3)–I Reductive Elimination. Org. Chem. Front. 2015, 2, 1080-1084.
10. Hao, W.; Geng, W.; Zhang, W.-X.; Xi, Z. Palladium-Catalyzed One-Pot Three- or Four-Component Coupling of Aryl Iodides, Alkynes, and Amines through C-N Bond Cleavage: Efficient Synthesis of Indole Derivatives. Chem. Eur. J. 2014, 20, 2605-2612.
11. Gnaim, S.; Bauer, A.; Zhang, H.-J.; Chen, L.; Gannet, C.; Malapit, C. A.; Hill, D.; Vogt, D.; Tang, T.; Daley, R.; Hao, W.; Zeng, R.; Quertenmont, M.; Beck, W. D.; Kandahari, E.; Vantourout, J. C.; Echeverria, P.-G.; Abruna, H.; Blackmond, D. G.; Minteer, S.; Reisman, S.; Sigman, M. S.; Baran P. S. Cobalt-electrocatalytic HAT for Functionalization of Unsaturated C–C Bonds. Nature, 2022, 605, 687-695.
12. Huang, Y.; † Knouse, K. W.; † Qiu, S.; † Hao, W.; ‡ Padial, N. M.; ‡ Vantourout, J. C.; ‡ Zheng, B.; Mercer, S. E.; Lopez, J. O.; Narayan, R.; Olson, R. E.; Blackmond, D. G.; Eastgate, M. D.; Schmidt, M. A.; McDonald, I. M.; Baran, P. S. A P(V)-Platform for Oligonucleotide Synthesis. Science 2021, 373, 1265-1270.
13. Gao, Y.; Hill D. E.; Hao, W.; McNicholas, B. J.; Vantourout, J. C.; Hadt, R. G.; Reisman, S. E.; Blackmond, D. G.; Baran, P. S. Electrochemical Nozaki–Hiyama–Kishi Coupling: Scope, Applications, and Mechanism. J. Am. Chem. Soc. 2021, 143, 9478-9488.
14. Ouyang, K., Hao, W.; Zhang, W.-X.; Xi, Z. Transition-Metal-Catalyzed Cleavage of C–N Single Bonds. Chem. Rev. 2015, 115, 12045-12090.